St. Lucius I: …Lucius opposed and condemned the Novatian Schism, a rigorist movement against penitent apostates, inspired by the antipope Novatian. Lucius’s martyrdom in the Valerian persecution is unproven. He was succeeded by St. Stephen I.

Novatian was the second antipope in papal history, in 251. He was the first Roman theologian to write in Latin and inspired the Novatian Schism—a break from the Christian church by rigorists who condemned apostasy. (His name was certainly Novatianus—not Novatus, as given by the Greeks.) Novatian

Novato, city, Marin county, western California, U.S. Located about 30 miles (50 km) north of San Francisco, it lies along Novato Creek, between San Pablo Bay (east) and Point Reyes National Seashore (west). The area was once the territory of Miwok Indians. Ownership of the land was granted to

Junius Gallio was a Roman official who dismissed the charges brought by the Jews against the apostle Paul (Acts 18:12–17). The elder brother of the philosopher and tragedian Lucius Annaeus Seneca, Novatus assumed the name Gallio after his adoption by the senator Junius Gallio. Upon the accession of

COVID-19 vaccine: …in late 2020, and the Novavax COVID-19 vaccine, a protein-based vaccine that initially was made available in Europe in 2021.

Mikhail Gorbachev: Later life of Mikhail Gorbachev: …half of the independent newspaper Novaya Gazeta, known for its willingness to challenge Kremlin policies. On September 30, 2008, it was announced that Gorbachev and Lebedev were forming a new political party, though it never materialized. Although Gorbachev was at times critical of Russian leader Vladimir Putin, he supported the…

Mikhail Mikhaylovich, Count Speransky: Secretary to the Emperor.: …the prime mover in founding Severnaya pochta or Novaya Sankt-Petersburgskaya gazeta, Russia’s first official newspaper. In 1807 he became intimately associated with the Emperor himself, as his administrative secretary and assistant. In 1808 he accompanied Alexander to his meeting with Napoleon, who described him as “the only clear head in…

Novaya Zemlya, archipelago in northwestern Russia, lying in the Arctic Ocean and separating the Barents and Kara seas. Novaya Zemlya (“New Land”) consists of two large islands, Severny (northern) and Yuzhny (southern), aligned for 600 miles (1,000 km) in a southwest-northeast direction, plus

Kara Sea: …of Novaya Zemlya stretches the Novaya Zemlya Trough, 650–1,300 feet (200–400 metres) deep.

Czechoslovak history: The Luxembourg dynasty: …by attaching a new borough, Nové město (New Town), which increased the population to about 30,000. In 1348 he founded in Prague the first university in the empire. It consisted of four traditional faculties (theology, law, medicine, and liberal arts), and its members were grouped into four nations (Bohemian, Bavarian,…

Nove ware, primarily majolica, or tin-glazed earthenware, made in Nove, Italy, in the 18th century. The factory was founded by Giovanni Battista Antonibon in 1728, and in the latter part of the century it had connections with a factory in nearby Bassano, where majolica had been made two centuries

Osman Lins: …works that secured his reputation: Nove, Novena (1966; Nine, Novena), consisting of nine narratives; Avalovara (1973; Eng. trans. Avalovara), a novel; and A rainha dos cárceres da Grécia (1976; The Queen of the Prisons of Greece). These works subject fictional narrative to an order determined by external elements of “literary…

Spanish literature: Novecentismo: The term novecentistas applies to a generation of writers that fall between the Generation of 1898 and the vanguardist Generation of 1927. The novecentistas—sometimes also called the Generation of 1914—were more classical and less revolutionary than their predecessors. They sought to renew intellectual and…

Novecento movement, group of Italian artists, formed in 1922 in Milan, that advocated a return to the great Italian representational art of the past. The founding members of the Novecento (Italian: 20th-century) movement were the critic Margherita Sarfatti and seven artists: Anselmo Bucci, Leonardo

novel, an invented prose narrative of considerable length and a certain complexity that deals imaginatively with human experience, usually through a connected sequence of events involving a group of persons in a specific setting. Within its broad framework, the genre of the novel has encompassed an

Valentinian III: …the Great, issued the famous Novel 17, which assigned to the bishop of Rome supremacy over the provincial churches. During the closing years of Valentinian’s reign, the Huns invaded Gaul (451) and northern Italy (452), but it is not known whether Valentinian personally played any significant part in meeting these…

adverse possession: …known as the assize of novel disseisin. If the land held by a disseisor was claimed by an heir of the original owner in seisin, the heir could bring a similar legal action known as the assize of mort d’ancestor. After the 17th century more expeditious legal actions were developed.

adverse possession: …known as the assize of novel disseisin. If the land held by a disseisor was claimed by an heir of the original owner in seisin, the heir could bring a similar legal action known as the assize of mort d’ancestor. After the 17th century more expeditious legal actions were developed.

novel of manners, work of fiction that re-creates a social world, conveying with finely detailed observation the customs, values, and mores of a highly developed and complex society. The conventions of the society dominate the story, and characters are differentiated by the degree to which they

sentimental novel, broadly, any novel that exploits the reader’s capacity for tenderness, compassion, or sympathy to a disproportionate degree by presenting a beclouded or unrealistic view of its subject. In a restricted sense the term refers to a widespread European novelistic development of the

Bonaventure Des Périers: …Mirth and Pleasant Conceits, or Novel Pastimes and Merry Tales), the collection of stories and fables on which his fame rests, appeared at Lyon in 1558. The stories are models of simple, direct narration in the vigorous, witty, and picturesque French of the 16th century.

neōteros: …later a group called the novel poets modeled themselves after the neōteroi, writing in Greek and following Greek models.

Latin American literature: The modern novel: …and dramatic contradiction made the novela de la tierra the literary tradition within which and counter to which new novelistic projects were measured.

María de Zayas y Sotomayor: Novelas amorosas y ejemplares (1637; “Novels of Romance and Exemplary Tales”) is a collection of short novels about the romantic complications of married life, ostensibly told one evening to amuse a sick woman. The stories are mostly about women who are mistreated by husbands or…

Miguel de Cervantes: Publication of Don Quixote: The next year, the 12 Exemplary Stories were published. The prologue contains the only known verbal portrait of the author:

Benito Pérez Galdós: Known as the Novelas españolas contemporáneas (“Contemporary Spanish Novels”), these books were written at the height of the author’s literary maturity and include some of his finest works, notably La desheredada (1881; The Disinherited Lady) and his masterpiece, the four-volume novel Fortunata y Jacinta (1886–87), a study of…

Miguel de Cervantes: Publication of Don Quixote: The next year, the 12 Exemplary Stories were published. The prologue contains the only known verbal portrait of the author:

novella, short and well-structured narrative, often realistic and satiric in tone, that influenced the development of the short story and the novel throughout Europe. Originating in Italy during the Middle Ages, the novella was based on local events that were humorous, political, or amorous in

novel, an invented prose narrative of considerable length and a certain complexity that deals imaginatively with human experience, usually through a connected sequence of events involving a group of persons in a specific setting. Within its broad framework, the genre of the novel has encompassed an

novella, short and well-structured narrative, often realistic and satiric in tone, that influenced the development of the short story and the novel throughout Europe. Originating in Italy during the Middle Ages, the novella was based on local events that were humorous, political, or amorous in

Code of Justinian: The Novellae Constitutiones Post Codicem (or simply, in English, the Novels) comprised several collections of new ordinances issued by Justinian himself between 534 and 565, after publication of the revised Codex.

Camilo Castelo Branco: …Minho rural life in his Novellas do Minho (1875–77) approach naturalism, he engaged in a literary quarrel with the emergent naturalist school and parodied their style and subjects in Eusébio Macário (1879) and A corja (1880; “The Rabble”). Nevertheless, while continuing to express vehement opposition to naturalism, he more and…

Matteo Bandello: …was an Italian writer whose Novelle (stories) started a new trend in 16th-century narrative literature and had a wide influence in England, France, and Spain.

Edmondo De Amicis: …in Italy, 1882), followed by Novelle (1872; “Short Stories”), which some critics have thought his best work. He also wrote poetry (collected in Poesie, 1880), novels, travelogues, and essays. But his most important work is the sentimental children’s story Cuore (1886; 1st Eng. trans., 1887; best trans., The Heart of…

novella: …it is known as the Novelle, in the 18th, 19th, and early 20th centuries in the works of writers such as Heinrich von Kleist, Gerhart Hauptmann, J.W. von Goethe, Thomas Mann, and Franz Kafka. As in Boccaccio’s Decameron, the prototype of the form, German Novellen are often encompassed within a…

Giovanni Battista Casti: …wrote his witty society verse Novelle galanti (“Amatory Tales”), first published in a critical edition in 1925. In 1778 Casti visited the court of Catherine the Great in St. Petersburg; though he was treated well, his Poema tartaro mocked the adulation shown the Empress. Returning to Vienna, he was named…

Italian literature: Prose: …until 1525, with the title Le ciento novelle antike [“A Hundred Old Tales”; Eng. trans. Il Novellino: The Hundred Old Tales]). The masterpiece of 13th-century prose is Dante’s Vita nuova. Though not yet completely at ease in vernacular prose, Dante combined simplicity with great delicacy and a poetic power that…

Italian literature: Prose: …until 1525, with the title Le ciento novelle antike [“A Hundred Old Tales”; Eng. trans. Il Novellino: The Hundred Old Tales]). The masterpiece of 13th-century prose is Dante’s Vita nuova. Though not yet completely at ease in vernacular prose, Dante combined simplicity with great delicacy and a poetic power that…

Antonia Novello is a Puerto Rican-born physician and public official, the first woman and the first Hispanic to serve as surgeon general of the United States (1990–93). Antonia Coello suffered from a painful colon condition from birth until she underwent corrective surgery at age 18. This

Ivor Novello was a Welsh actor-manager, composer, and playwright, best known for his lush, sentimental, romantic musicals. Novello, the son of the celebrated Welsh singing teacher, Dame Clara Novello Davies, was educated at Magdalen College, Oxford, and served with the Royal Naval Air Service

Charles Cowden Clarke: …Charles Dickens, and Felix Mendelssohn, Clarke became a partner in music publishing with Alfred Novello, whose sister, Mary, he married in 1828. Six years later Clarke began his public lectures on Shakespeare and other dramatists and poets. Those published include Shakespeare Characters; Chiefly Those Subordinate (1863) and Molière Characters (1865).…

Vincent Novello was an English composer, conductor, and founder of the Novello music publishing house. From 1797 to 1822 Novello was organist at the Portuguese embassy chapel, where he directed the first English performances of masses by Joseph Haydn and W.A. Mozart. In 1812 he became pianist and

Code of Justinian: The Novellae Constitutiones Post Codicem (or simply, in English, the Novels) comprised several collections of new ordinances issued by Justinian himself between 534 and 565, after publication of the revised Codex.

history of film: Edison and the Lumière brothers: …been characterized as the “novelty period,” emphasis fell on the projection device itself, and films achieved their main popularity as self-contained vaudeville attractions. Vaudeville houses, locked in intense competition at the turn of the century, headlined the name of the machines rather than the films (e.g., “The Vitascope—Edison’s Latest…

novelty song, popular song that is either written and performed as a novelty or that becomes a novelty when removed from its original context. Regardless of which of these two categories applies, the assumption is that the song is popular because of its novelty, because it sounds different from

textile: Novelty yarns: Novelty yarns include a wide variety of yarns made with such special effects as slubs, produced by intentionally including small lumps in the yarn structure, and synthetic yarns with varying thickness introduced during production. Natural fibres, including some linens, wools to be woven…

submarine: Nuclear propulsion: …first nuclear submarines, of the November class, entered service in 1958. Since the dissolution of the Soviet Union in 1991, Russia has continued the policy of maintaining a mixed nuclear-conventional submarine force. In 1968 the Chinese began to build nuclear submarines while continuing to build and purchase large numbers of…

November, 11th month of the Gregorian calendar. Its name is derived from novem, Latin for “nine,” an indication of its position in the early Roman

David Mamet: Mamet’s later plays included November (produced 2008), a farcical portrait of a U.S. president running for reelection; Race (produced 2009), a legal drama that explores racial attitudes and tensions; The Anarchist (produced 2012), which depicts a charged meeting between a women’s prison official and an inmate seeking parole; China…

Paris attacks of 2015, coordinated terrorist attacks that took place in Paris on the evening of November 13, 2015. At least 130 people were killed and more than 350 were injured. France was shaken on January 7, 2015, by a deadly assault on the offices of satiric magazine Charlie Hebdo. A pair of

Colleen Hoover: In November 9 (2015) a woman has a chance encounter with a writer, who uses her as inspiration for his novel. They continue to meet every year, but she begins to question what is real and what is fiction. Verity (2018) was something of a departure…

Novembergruppe, group of artists from many media formed in Berlin in December 1918 by Max Pechstein and César Klein. Taking its name from the month of the Weimar Revolution, which occurred in Germany immediately after World War I, the Novembergruppe hoped to bring about a new unity in art,

November Insurrection, (1830–31), Polish rebellion that unsuccessfully tried to overthrow Russian rule in the Congress Kingdom of Poland as well as in the Polish provinces of western Russia and parts of Lithuania, Belorussia, (now Belarus), and Ukraine. When a revolution broke out in Paris (July

Pierce Brosnan: …people, and in the thriller The November Man, in which he portrayed a retired CIA agent who is pulled onto a high-stakes mission. The next year Brosnan appeared in No Escape as an undercover British agent who assists a family in escaping from a fictional Asian country in the midst…

cinquain: An example is her poem “November Night”:

Kristallnacht, the night of November 9–10, 1938, when German Nazis attacked Jewish persons and property. The name Kristallnacht refers ironically to the litter of broken glass left in the streets after these pogroms. The violence continued during the day of November 10, and in some places acts of

October Revolution, (Oct. 24–25 [Nov. 6–7, New Style], 1917), the second and last major phase of the Russian Revolution of 1917, in which the Bolshevik Party seized power in Russia, inaugurating the Soviet regime. See Russian Revolution of

Sweden: Change in alliance policy: …this intention, he signed the November Treaty with the Western powers in 1855. The peace treaty that was concluded in Paris shortly afterward, however, ended the hopes cherished in Sweden of winning Finland, or at least Åland, back again. All that was gained was the Åland Convention, which forbade Russia…

Novembergruppe, group of artists from many media formed in Berlin in December 1918 by Max Pechstein and César Klein. Taking its name from the month of the Weimar Revolution, which occurred in Germany immediately after World War I, the Novembergruppe hoped to bring about a new unity in art,

France: The shrinking of the frontiers and peripheral areas: …in 578 and settled in Novempopulana; in spite of several Frankish expeditions, this area was not subdued. In the south the Franks were unable to gain control of Septimania; they tried to accomplish this by means of diplomatic agreements, which were buttressed by dynastic intermarriage, and by military campaigns occasioned…

Auch, town, capital of Gers département, Occitanie région, southwestern France. Auch is built on and around a hill on the west bank of the Gers River, west of Toulouse. The capital of the Celtiberian tribe of Ausci, it became important in Roman Gaul as Elimberris and, after Christianity was

novena, in Christianity, a term designating a spiritual devotion consisting of the recitation of a set form of prayer for nine consecutive days, in petition for a divine favour or in preparation for a liturgical feast or as participation in an important event such as a Year of Jubilee. Novena

Generation of 1898, in Spain, the novelists, poets, essayists, and thinkers active at the time of the Spanish-American War (1898), who reinvigorated Spanish letters and restored Spain to a position of intellectual and literary prominence that it had not held for centuries. The shock of Spain’s

József, Baron Eötvös: …poetry and only one novel, Nővérek (1857; “The Sisters”), which explained his ideas on education. Yet his literary work is of great importance. His short stories mark the beginning of a new portrayal of the peasant in Hungarian literature, and at a time when the Romantic novel was in fashion…

Jean-Georges Noverre was a distinguished French choreographer whose revolutionary treatise, Lettres sur la danse et sur les ballets (1760), still valid, brought about major reforms in ballet production, stressing the importance of dramatic motivation, which he called ballet d’action, and decrying

Veliky Novgorod, city and administrative centre of Novgorod oblast (region), northwestern Russia, on the Volkhov River just below its outflow from Lake Ilmen. Veliky Novgorod (commonly shortened to Novgorod) is one of the oldest Russian cities, first mentioned in chronicles of 859. In 882 Oleg,

Novgorod, oblast (region), northwestern Russia, extending across the morainic Valdai Hills, which rise to 971 feet (296 metres); the lowland basins of Lake Ilmen lie to the west and of the upper Volga River to the east. Much of the oblast’s terrain is in swamp of peat bog or reed and grass marsh,

Novgorod school, important school of Russian medieval icon and mural painting that flourished around the northwestern city of Novgorod from the 12th through the 16th century. A thriving merchant city, Novgorod was the cultural centre of Russia during the Mongol occupation of most of the rest of the

museum: History museums: ; and the Novgorod State Museum Preserve in Russia.

Treaty of Novgorod, (June 3, 1326), the peace treaty ending decades of hostilities between the principality of Novgorod (now in Russia) and Norway. The conflicts took place in what was then generally known as Finnmark (including the present Norwegian province of Finnmark and Russia’s Kola

Novhorod-Siverskyy, city, northern Ukraine. The city emerged probably in the late 10th century. In the 11th century it was the centre of the Siversk principality in Kievan Rus. It was under Lithuanian (1356–1503), Russian (1503–1618), and Polish (1618–54) rule before becoming a part of the

Novhorod-Siverskyy, city, northern Ukraine. The city emerged probably in the late 10th century. In the 11th century it was the centre of the Siversk principality in Kievan Rus. It was under Lithuanian (1356–1503), Russian (1503–1618), and Polish (1618–54) rule before becoming a part of the

Novhorod-Siverskyy, city, northern Ukraine. The city emerged probably in the late 10th century. In the 11th century it was the centre of the Siversk principality in Kievan Rus. It was under Lithuanian (1356–1503), Russian (1503–1618), and Polish (1618–54) rule before becoming a part of the

Bar, port in Montenegro, on the Adriatic Sea. It is the country’s principal port. The current city is known as Novi (“New”) Bar. Stari (“Old”) Bar’s ruins lie farther inland at the base of Mount Rumija. Stari Bar was first mentioned in the 9th century, when it came under the control of the

Belgrade: A new district called New Belgrade (Novi Beograd) has been built on the plain west of the old city, between the Sava and Danube rivers. The old fortress of Kalemegdan is now a historical monument; its former glacis has been rebuilt as a garden, from which is seen a…

history of film: Russia, eastern Europe, and Central Asia: …late 1960s movement known as Novi Film (New Film), which also included such directors as Puriša Djordjević, Aleksandar Petrović, and Živojin Pavlović, all of whom were temporarily purged from the film industry during a reactionary period in the early 1970s. This dark period came to an end in 1976 when…

Novi Ligure, town, Piedmont regione (region), northwestern Italy, north of Genoa. A free commune until 1192, it then fell successively to Tortona and Milan before passing to Genoa in 1447. It was the scene of an Austro-Russian army’s defeat of the French in 1799. Novi Ligure is now an important

Novi Pazar, town, southwestern Serbia. It lies in the Raška River valley, in rough and hilly country near the site of Ras, which was the capital city of the medieval Serbian state in the 12th–14th century. Roman baths are in the vicinity of the town, as is the Church of St. Peter (7th or 8th

Novi Sad, city and administrative capital of the ethnically mixed autonomous region of Vojvodina in northern Serbia. It is a transit port on the heavily trafficked Danube River northwest of Belgrade and is also situated on the Belgrade-Budapest rail line. Before the 18th century Novi Sad was a

Novial, artificial language constructed in 1928 by the Danish philologist Otto Jespersen, intended for use as an international auxiliary language, but little used today. Its grammar is similar in type to that of Esperanto or Ido. Novial has one definite article, no gender for nouns except those

thought: Expert thinking and novice thinking: Research by the American psychologists Herbert A. Simon, Robert Glaser, and Micheline Chi, among others, has shown that experts and novices think and solve problems in somewhat different ways. These differences explain why experts are more effective than novices in a variety of…

Italian literature: Other writings: …boundaries (La suora giovane [1959; The Novice] and Il fratello italiano [1980; “The Italian Brother”]). Fulvio Tomizza also tackled this theme in L’amicizia (1980; “The Friendship”).

Novichok, group of organophosphate chemicals that act as nerve agents and were designed for use as weapons of chemical warfare. Novichok agents were initially derived from organophosphate compounds in the so-called V (venomous) series, which includes the potent agent VR, as well as from chemicals

quasar: Discovery of quasars: …Russian astronomers Yakov Zel’dovich and Igor Novikov and Austrian American astronomer Edwin Salpeter. The combination of high luminosities and small sizes was sufficiently unpalatable to some astronomers that alternative explanations were posited that did not require the quasars to be at the large distances implied by their redshifts. These alternative…

Nikolay Ivanovich Novikov was a Russian writer, philanthropist, and Freemason whose activities were intended to raise the educational and cultural level of the Russian people and included the production of social satires as well as the founding of schools and libraries. Influenced by Freemasonry,

Sergei Novikov is a Russian mathematician who was awarded the Fields Medal in 1970 for his work in topology. Novikov graduated from Moscow State University in 1960 and received Ph.D. (1964) and Doctor of Science (1965) degrees from the V.A. Steklov Institute of Mathematics in Moscow. He joined the

Sergei Novikov is a Russian mathematician who was awarded the Fields Medal in 1970 for his work in topology. Novikov graduated from Moscow State University in 1960 and received Ph.D. (1964) and Doctor of Science (1965) degrees from the V.A. Steklov Institute of Mathematics in Moscow. He joined the

Kragujevac: The first newspaper in Serbia, Novine Srbske, was published there. In 1941 German military authorities executed 7,000 males between the ages of 14 and 70 from the area of Kragujevac and Kraljevo; a monument recalls the massacre.

Speyer, city, Rhineland-Palatinate Land (state), southwestern Germany. Speyer is a port on the left bank of the Rhine River at the mouth of the Speyer River, south of Ludwigshafen. An ancient Celtic settlement, about 100 bce it became a Roman military and trading town, Noviomagus, and later became

Lisieux, town, formerly capital of the district known as the Pays d’Auge, Calvados département, Normandy région, northwestern France. Lisieux has become a world centre of pilgrimage to the shrine of St. Thérèse, a Carmelite nun who died there in 1897 and was canonized in 1925. Lisieux was also

Chichester, city, Chichester district, administrative county of West Sussex, historic county of Sussex, southern England. It lies on the coastal plain of the English Channel at the foot of the chalk South Downs about 1 mile (1.6 km) from the head of Chichester Harbour, with which it is connected by

Italian literature: Experimentalism and the new avant-garde: …there appeared the important anthology-manifesto I Novissimi: poesie per gli anni ’60 (“The Newest Poets: Poems for the ’60s”), edited by Alfredo Giuliani. In addition to the editor, the poets represented were Elio Pagliarani, author of La ragazza Carla (1960; “The Girl Carla”), a longish poem incorporating found materials and…

Nola, town and episcopal see, Campania regione, southern Italy. It lies in the fertile and highly cultivated Campanian plain, just east-northeast of Naples. It originated as a city of the Aurunci, Oscans, Etruscans, and Samnites (ancient Italic peoples) and was known as Novla (“New Town”) before it

Sitka, city and borough, southeastern Alaska, historically the most notable Alaskan settlement. U.S. Situated 95 miles (150 km) southwest of Juneau, on the western coast of Baranof Island in the Alexander Archipelago, it is the only city in southeastern Alaska that lies on the Pacific Ocean. The

Novo Hamburgo, city, eastern Rio Grande do Sul estado (state), southern Brazil. It lies 115 feet (35 metres) above sea level. Novo Hamburgo was founded by Germans in 1927 and named for Hamburg, Germany. An industrial city, it manufactures shoes, hides, and leather from the cattle and hogs raised in

Novo Mesto, city, southern Slovenia, on the Krka River. Novo Mesto was founded in 1365 by Rudolf IV of Austria and became an important military base on the Ottoman frontier in the 15th century. Though ravaged twice by fire (1576 and 1664) and once by plague (1599), Novo Mesto developed into an

Novo Nordisk A/S is an international pharmaceutical research, development, and manufacturing corporation established in 1989 through the merger of competing Danish companies Nordisk Insulaboratorium and Novo Terapeutisk Laboratorium. It specializes primarily in four areas of pharmacological

Anadyr, town and administrative centre, Chukchi autonomous okrug (district), far northeastern Russia. It lies on the southern shore of the estuary of the Anadyr River, which empties into the Bering Sea. Incorporated as a town in 1965, it is a port on the Northern Sea Route and has a meteorologic

Bulgarian literature: …this was the formation of novobulgarski, the new (or modern) literary Bulgarian language based on the vernacular of its eastern dialects, as opposed to the medieval Church Slavonic, which until then had always been used for literary purposes. Pioneers in this were Bishop Sophrony, whose Nedelnik (1806; “Sunday-Book”) is the…

procaine hydrochloride, synthetic organic compound used in medicine as a local anesthetic. Introduced in 1905 under the trade name Novocaine, it became the first and best-known substitute for cocaine in local anesthesia. Generally used in a 1 to 10 percent saline solution, procaine hydrochloride is