porphobilinogen deaminase

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porphobilinogen deaminase

enzyme

Also known as: uroporphyrinogen I synthetase

Learn about this topic in these articles:

metabolic disorders

In metabolic disease: Porphyrias
…a deficiency of the enzyme porphobilinogen deaminase. Symptoms usually arise during adolescence, and hormonal changes (e.g., menstruation), alcohol ingestion, certain foods, and some drugs may exacerbate the condition. Diagnosis is made by detecting porphyrins in the urine. Treatment is by administration of heme during acute attacks. A high-
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