Trypanosoma brucei gambiense
organism
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sleeping sickness
- In sleeping sickness
…infection with the flagellate protozoan Trypanosoma brucei gambiense or the closely related subspecies T. brucei rhodesiense, transmitted by the tsetse fly (genus Glossina). Sleeping sickness is characterized by two stages of illness. In the first stage, infected persons typically experience fever, headache, muscle and joint
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…of the disease caused by T. brucei gambiense. Both organisms can eventually invade the brain, causing mental deterioration, coma, and death.
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treatment with eflornithine
- In eflornithine
Eflornithine is effective only against Trypanosoma brucei gambiense, which causes Gambian (or West African) sleeping sickness. It is not effective against T. brucei rhodesiense, which causes Rhodesian (or East African) sleeping sickness.
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