Oparin-Haldane theory
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- Related Topics:
- Miller-Urey experiment
- abiogenesis
Oparin-Haldane theory, idea that organic molecules could be formed from abiogenic materials in the presence of an external energy source—e.g., ultraviolet radiation—and that Earth’s primitive atmosphere was reducing (having very low amounts of free oxygen) and contained ammonia and water vapour, among other gases. The theory emerged in the 1920s, when British scientist J.B.S. Haldane and Russian biochemist Aleksandr Oparin independently set forth similar ideas concerning the conditions required for the origin of life on Earth.
Haldane and Oparin both suspected that the first life-forms appeared in the warm, primitive ocean and were heterotrophic (obtaining preformed nutrients from the compounds in existence on early Earth) rather than autotrophic (generating food and nutrients from sunlight or inorganic materials). Oparin thought that life developed from coacervates, microscopic spontaneously formed spherical aggregates of lipid molecules that are held together by electrostatic forces and that may have been precursors of cells. Oparin’s work with coacervates confirmed that enzymes fundamental for the biochemical reactions of metabolism functioned more efficiently when contained within membrane-bound spheres than when free in aqueous solutions. Haldane, unfamiliar with Oparin’s coacervates, thought that simple organic molecules formed first and in the presence of ultraviolet light became increasingly complex, ultimately forming cells. Haldane and Oparin’s ideas formed the foundation for much of the research on abiogenesis that took place in later decades.
In 1953 American chemists Harold C. Urey and Stanley Miller tested the Oparin-Haldane theory and successfully produced organic molecules from some of the inorganic components thought to have been present on prebiotic Earth. This became known as the Miller-Urey experiment. Modern abiogenesis hypotheses are based largely on the same principles as the Oparin-Haldane theory and the Miller-Urey experiment. Subtle differences exist, however, between the several models that have been set forth, and explanations differ as to whether complex organic molecules first became self-replicating entities lacking metabolic functions or first became metabolizing protocells that then developed the ability to self-replicate.
