Owensboro, city, seat (1815) of Daviess county, on the Ohio River in western Kentucky, U.S., 32 miles (51 km) southeast of Evansville, Indiana. Founded about 1800, it was known to early flatboat men as Yellow Banks, from the colour of the clay along its high riverbanks. The town, laid out in 1816, was named Owensborough (later Owensboro) to honour Colonel Abraham Owen, a veteran of early Kentucky wars. During the American Civil War, it was the site of the Union Camp Silas B. Miller. A Confederate attack was repelled in 1862, but, in August 1864, guerrillas attacked and burned part of the town, including the courthouse.
The city is the centre of a rich oil and agricultural (tobacco, corn [maize], wheat, soybeans, and fruit) region. Manufactures include bourbon whiskey, aluminum, high-grade steel, chemicals, paper, furniture, food products, plastics, and smokeless tobacco. Service industries and tourism are also important to the economy. It is the site of Kentucky Wesleyan (1858) and Brescia (1950) colleges, the Museum of Science and History, and the International Bluegrass Music Museum. Inc. town, 1817; city, 1866. Pop. (2000) 54,067; Owensboro Metro Area, 103,875; (2010) 57,265; Owensboro Metro Area, 114,752.