Leslie Leiserowitz

Leslie Leiserowitz (born April 9, 1934, Johannesburg, South Africa) is an Israeli chemist known for his work, conducted in collaboration with Israeli chemist Meir Lahav, on the crystal forms of organic molecules.

Leiserowitz received a bachelor’s degree in electrical engineering from the University of Cape Town (UCT) in 1956. Shortly after graduating, while Leiserowitz was working at Philips-Denby, a company that made microwave equipment, “he became acutely aware of his ignorance of the structures of the various materials that were the engineer’s stock-in-trade,” as he later wrote. To further his knowledge, he read X Rays and Crystal Structure (1915), by William and Lawrence Bragg, which inspired him to return to UCT to study X-ray crystallography. He received a master’s degree in physics in 1959 and immigrated to Israel.

Leiserowitz earned a doctorate in solid-state chemistry from the Weizmann Institute of Science, in Rehovot, Israel, in 1965. He was briefly a postdoctoral fellow at the University of Heidelberg from 1966 to 1968 and then returned to the Weizmann Institute, where he spent the remainder of his career, becoming an associate professor in 1980, a full professor in 1983, and a professor emeritus in 2003.

In 1848 French chemist Louis Pasteur had discovered sodium ammonium tartrate crystals were enantiomorphous (that is, they came in two kinds that are mirror images of each other); Pasteur posited that this arose from sodium ammonium tartrate having two molecular structures that were mirror images of each other (that is, having different handedness, or “chirality”). However, how exactly enantiomorphous crystals related to the chiral molecules remained an open question.

Beginning in the 1970s Leiserowitz, Lahav, and their collaborators began a series of experiments in which they added auxiliary molecules to chiral molecules. The auxiliary molecule would affect the growth of the crystal of the chiral molecule, which would reveal how the molecules were arranged within the crystal. Their work found wide application, and Leiserowitz himself applied the new knowledge of crystal growth to the formation of cholesterol and research into how anti-malarial drugs could block the formation of hemozoin crystals, a process necessary to the Plasmodium parasite’s survival.

Leiserowitz has been honored with the Gregori Aminoff Prize from the Royal Swedish Academy of Science (2002, shared with Lahav) and the Wolf Prize in Chemistry (2021, shared with Lahav).